There is growing evidence that intracellular calcium plays a primary role in the
pathophysiology of the pancreas in addition to its crucial importance in major physiological
functions. Pancreatic acinar cells have a remarkably large amount of Ca 2+ stored in both
the endoplasmic reticulum (ER) and the acidic stores. The vast majority of the classical ER
Ca 2+ store is located in the basal part of the acinar cells with extensions protruding into the
apical area, however, the acidic stores are exclusively located in the secretory granular area …