Lysosomes are membrane-bound endocytic organelles that play a major role in degrading
cell macromolecules and recycling their building blocks. A comprehensive knowledge of the
lysosome function requires an extensive description of its content, an issue partially
addressed by previous proteomic analyses. However, the proteins underlying many
lysosomal membrane functions, including numerous membrane transporters, remain
unidentified. We performed a comparative, semi-quantitative proteomic analysis of rat liver …