[PDF][PDF] JNK regulates expression and autocrine signaling of TGF-β1
C Pardoux, R Derynck - Molecular Cell, 2004 - cell.com
C Pardoux, R Derynck
Molecular Cell, 2004•cell.comTGF-β1 can induce its own expression by an autoregulatory mechanism. In this issue of
Molecular Cell, Ventura et al.(2004) show, using JNK-deficient fibroblasts, that JNK
negatively regulates TGF-β1 gene expression and, consequently, autocrine TGF-β
signaling. The results highlight the contributions of JNK signaling in the control of TGF-β
expression and signaling, and of autocrine TGF-β signaling in the JNK-regulated changes in
cell behavior.
Molecular Cell, Ventura et al.(2004) show, using JNK-deficient fibroblasts, that JNK
negatively regulates TGF-β1 gene expression and, consequently, autocrine TGF-β
signaling. The results highlight the contributions of JNK signaling in the control of TGF-β
expression and signaling, and of autocrine TGF-β signaling in the JNK-regulated changes in
cell behavior.
Abstract
TGF-β1 can induce its own expression by an autoregulatory mechanism. In this issue of Molecular Cell, Ventura et al. (2004) show, using JNK-deficient fibroblasts, that JNK negatively regulates TGF-β1 gene expression and, consequently, autocrine TGF-β signaling. The results highlight the contributions of JNK signaling in the control of TGF-β expression and signaling, and of autocrine TGF-β signaling in the JNK-regulated changes in cell behavior.
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