Severe cutaneous adverse reactions include syndromes such as drug reaction with
eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome
(DIHS) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). An
important advance has been the discovery of associations between HLA alleles and many of
these syndromes, including abacavir-associated hypersensitivity reaction, allopurinol-
associated DRESS/DIHS and SJS/TEN, and SJS/TEN associated with aromatic amine …