Background: Drugs can induce different immunologic reactions; T-cell mediated responses
produce the most severe reactions. Although in vitro studies show that T cells recognize
drugs or their metabolites and induce an effector cytotoxic response, direct in vivo evidence
of involvement is lacking. T lymphocytes produce cytotoxic markers that are responsible for 2
major pathways to cell death: granule-mediated exocytosis (perforin and granzyme B) and
Fas/FasL interaction. Objective: The purpose of this investigation was to establish the role of …