Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome
CY Wei, WH Chung, HW Huang, YT Chen… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Increasing studies have revealed that HLA alleles are the major genetic
determinants of drug hypersensitivity; however, the underlying molecular mechanism
remains unclear. OBJECTIVE: We adopted the HLA-B∗ 1502 genetic predisposition to
carbamazepine (CBZ)–induced Stevens-Johnson syndrome (SJS)/toxic epidermal
necrolysis (TEN) as a model to study the pathologic role of HLA in delayed-type drug
hypersensitivity. METHODS: We in vitro expanded CBZ-specific cytotoxic T lymphocytes …
determinants of drug hypersensitivity; however, the underlying molecular mechanism
remains unclear. OBJECTIVE: We adopted the HLA-B∗ 1502 genetic predisposition to
carbamazepine (CBZ)–induced Stevens-Johnson syndrome (SJS)/toxic epidermal
necrolysis (TEN) as a model to study the pathologic role of HLA in delayed-type drug
hypersensitivity. METHODS: We in vitro expanded CBZ-specific cytotoxic T lymphocytes …