[HTML][HTML] Transforming growth factor beta expression by human vascular cells inhibits interferon gamma production and arterial media injury by alloreactive memory T …
AH Lebastchi, SF Khan, L Qin, W Li, J Zhou… - American Journal of …, 2011 - Elsevier
Arteriosclerosis is characterized by the local activation of effector T cells leading to
production of proinflammatory cytokines, such as IFN (interferon)-γ and IL-17, within the
vessel wall. Conversely, the production of antiinflammatory cytokines, for example, TGF-β,
by regulatory lymphocytes is known to inhibit both the differentiation of naïve T cells into
effector T cells and the development of arteriosclerosis in murine models. We investigated
the role of TGF-β on the alloreactivity of human effector memory T cells (Tem). Quiescent …
production of proinflammatory cytokines, such as IFN (interferon)-γ and IL-17, within the
vessel wall. Conversely, the production of antiinflammatory cytokines, for example, TGF-β,
by regulatory lymphocytes is known to inhibit both the differentiation of naïve T cells into
effector T cells and the development of arteriosclerosis in murine models. We investigated
the role of TGF-β on the alloreactivity of human effector memory T cells (Tem). Quiescent …
