Ototoxic drugs: difference in sensitivity between mice and guinea pigs
AL Poirrier, P Van Den Ackerveken, TS Kim… - Toxicology letters, 2010 - Elsevier
The development of experimental animal models has played an invaluable role in
understanding the mechanisms of neurosensory deafness and in devising effective
treatments. The purpose of this study was to develop an adult mouse model of ototoxic drug-
induced hearing loss and to compare the ototoxicity in the adult mouse to that in the well-
described guinea pig model. Mice are a powerful model organism, especially due to the
large availability of antibodies, probes and genetic mutants. In this study, mice (n= 114) and …
understanding the mechanisms of neurosensory deafness and in devising effective
treatments. The purpose of this study was to develop an adult mouse model of ototoxic drug-
induced hearing loss and to compare the ototoxicity in the adult mouse to that in the well-
described guinea pig model. Mice are a powerful model organism, especially due to the
large availability of antibodies, probes and genetic mutants. In this study, mice (n= 114) and …