[HTML][HTML] A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation
J Wang, VM Vock, S Li, OR Olivas… - Journal of Biological …, 2002 - ASBMB
Nonsense-mediated decay (NMD) is an RNA surveillance pathway that degrades mRNAs
containing premature termination codons (PTC). T-cell receptor (TCR) and immunoglobulin
(Ig) transcripts, which are encoded by genes that very frequently acquire PTCs during
lymphoid ontogeny, are down-regulated much more dramatically in response to PTCs than
are other known transcripts. Another feature unique to TCR, Ig, and a subset of other mRNAs
is that they are down-regulated in response to nonsense codons in the nuclear fraction of …
containing premature termination codons (PTC). T-cell receptor (TCR) and immunoglobulin
(Ig) transcripts, which are encoded by genes that very frequently acquire PTCs during
lymphoid ontogeny, are down-regulated much more dramatically in response to PTCs than
are other known transcripts. Another feature unique to TCR, Ig, and a subset of other mRNAs
is that they are down-regulated in response to nonsense codons in the nuclear fraction of …
