[HTML][HTML] Surfactant protein D gene regulation: interactions among the conserved CCAAT/enhancer-binding protein elements
Y He, E Crouch - Journal of Biological Chemistry, 2002 - ASBMB
Surfactant protein D (SP-D) plays roles in pulmonary host defense and surfactant
homeostasis and is increased following acute lung injury. Given the importance of
CCAAT/enhancer-binding protein (C/EBP)-binding elements in the systemic acute-phase
response and lung development and the expression of C/EBP isoforms by lung epithelial
cells, we hypothesized that conserved C/EBP motifs in the near-distal and proximal
promoters contribute to the regulation of SP-D expression by C/EBPs. Five SP-D motifs …
homeostasis and is increased following acute lung injury. Given the importance of
CCAAT/enhancer-binding protein (C/EBP)-binding elements in the systemic acute-phase
response and lung development and the expression of C/EBP isoforms by lung epithelial
cells, we hypothesized that conserved C/EBP motifs in the near-distal and proximal
promoters contribute to the regulation of SP-D expression by C/EBPs. Five SP-D motifs …
