Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence
DR Weinberger, KF Berman… - Archives of general …, 1986 - jamanetwork.com
• To evaluate dorsolateral prefrontal cortex (DLPFC) physiology and function
simultaneously, 20 medication-free patients with chronic schizophrenia and 25 normal
controls underwent three separate xenon Xe 133 inhalation procedures for determination of
regional cerebral blood flow (rCBF): first at rest, then while performing an automated version
of the Wisconsin Card Sort (WCS), a DLPFC-specific cognitive test, and while peforming a
simple number-matching (NM) test. During rest, patients had significantly reduced relative …
simultaneously, 20 medication-free patients with chronic schizophrenia and 25 normal
controls underwent three separate xenon Xe 133 inhalation procedures for determination of
regional cerebral blood flow (rCBF): first at rest, then while performing an automated version
of the Wisconsin Card Sort (WCS), a DLPFC-specific cognitive test, and while peforming a
simple number-matching (NM) test. During rest, patients had significantly reduced relative …
